Drug Discovery and Drug Development

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About this book

Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR.

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Keywords

• drug formulation
• pharmacology
• drug repurposing
• drug delivery
• pharmacokinetics
• biopharmaceutics

Table of contents (13 chapters)

Front Matter

Traditional Medical System (TMS) for Sustainable Healthcare in India

• Pulok K. Mukherjee, Subhadip Banerjee, Chandra Kant Katiyar, Shivani Sharma, Naibedya Chattopadhyay

Modern Drug Discovery and Development for TB: The India Narrative

• Tanjore S. Balganesh, Jagadeesh J. Bhat, Bheemarao Ugarkar

Indian Discovery Effort in the Quest of Novel Antibiotics

• Mahesh V. Patel, Sachin S. Bhagwat, Prasad K. Deshpande

New Drug Discovery and Development in India to Counter Malaria

• Niti Kumar, Saman Habib

Modern Drug Discovery and Development in the Area of Leishmaniasis

• Neena Goyal, Manveer Patel, Sanjay Batra

Introduction to Diabetes and Prevalence in India

• Parimal Misra, Ranjan Chakrabarti

Type 2 Diabetes Mellitus: Marketed Drugs and Mechanisms

• Parimal Misra, Ranjan Chakrabarti

Anti-diabetes Research in India: Contributions from Industrial Organizations

• Sarbani Pal, Manojit Pal

Indian Academia Tryst with Cardio-metabolic Drug Discovery and Development

• Manoj K. Barthwal

Modern Drug Discovery and Development in the Area of Cancer: Indian Context

• Tapas K. Kundu, Anand P. Kulkarni, Dipak Datta, Sweta Sikder

Biopharmaceutical Development in India: Recommendations on Collaboration and Innovation to Enable Affordable Healthcare

• Narendra Chirmule, Shilpa Bhat, Sabyasachi Mondal

Regulatory Requirements and Quality Standards in India’s Clinical Trials Journey

• Bobby George, Shrinivas Krishnarao Kulkarni, Nilima A. Kshirsagar

New Drug Discovery and Development: Indian Pharmaceutical Industry

• Nagarajan Kuppuswamy, Srinivas Nanduri, Venkateswarlu Akella

Editors and Affiliations

NCR Biotech Science Cluster, Translational Health Science and Technology Institute, Faridabad, India

About the editor

Dr Madhu Dikshit, a highly respected researcher and former Director of the CSIR-Central Drug Research Institute, Lucknow, India, has made significant contributions to the general area of Molecular Pharmacology with a special interest in redox biology. Dr Dikshit’s research has impacted the area of neutrophil biology by enhancing our understanding of e.g. chemotaxis, phagocytosis, apoptosis and also differentiation. Her pioneering work has helped identify the molecular mechanisms involved in the translocation of Nitric Oxide Synthase to the phagosomal compartment and the inflammatory potential of neutrophil extracellular traps. At the CSIR-CDRI, she initiated and led the successful anti-thrombotic drug discovery program, in the context of which two new chemical entities advanced to the pre-clinical stage and one has recently received approval for Phase I clinical trials. Dr Dikshit has published more than 170 papers in peer-reviewed journals, holds eight patents and has supervised more than 30 PhD students. Presently she is the National Chair at Translational Health Sciences & Technology Institute (THSTI), Faridabad and heads its Non-Communicable Disease Program.

Bibliographic Information

• Book Title : Drug Discovery and Drug Development
• Book Subtitle : The Indian Narrative
• Editors : Madhu Dikshit
• DOI : https://doi.org/10.1007/978-981-15-8002-4
• Publisher : Springer Singapore
• eBook Packages : Biomedical and Life Sciences , Biomedical and Life Sciences (R0)
• Copyright Information : Springer Nature Singapore Pte Ltd. 2021
• Hardcover ISBN : 978-981-15-8001-7 Published: 11 February 2021
• Softcover ISBN : 978-981-15-8004-8 Published: 11 February 2022
• eBook ISBN : 978-981-15-8002-4 Published: 10 February 2021
• Edition Number : 1
• Number of Pages : XIII, 376
• Number of Illustrations : 147 b/w illustrations, 44 illustrations in colour
• Topics : Pharmacology/Toxicology , Biotechnology , Biomedicine, general